The objective of this work was to evaluate in a model of chronic ulcer the antiulcer effect and the possible mechanisms by which this fruit produces gastroprotection. The pulp of the green fruit was sliced, dried at 50 ^oC, ground and sieved. Ninety Male Wistar rats of 190 ± 10 g were used.   The antiulcer effect of pulp was performed with the chronic model of ulcer by acetic acid, used 5 groups of 8 animal, the suspension of the pulp at 125; 250; 500 mg / kg BW were applied 72 hours after inducing the ulcer for 7 days. For the determination of the mechanisms, also 5 groups of 10 animal were used, the banana pulp was supplied in a dose of 125, 250 and 500 mg / kg of BW, for three days, before inducing the ulcers with indomethacin, the activity of the myeloperoxidase, the superoxide dismutase and the levels of prostaglandins in the gastric mucosa were determined. Treatment with the suspensions of the pulp in the chronic ulcer model reduced in a very highly significant way the damaged area in all the treated groups and this reduction was greater than that produced by ranitidine; there was a significant decrease in myeloperoxidase only with the highest dose tested and a significant increase of superoxide dismutase and prostaglandins level with all the doses used. We conclude that the pulp preparations provoked an intense anti-ulcer. The mechanism of gastroprotective action was mediated by an antioxidant effect and mucosal protection.

Alzheimer´s disease increases its global incidence and prevalence, the WHO includes the disease among the main problems in public health today. Cuba is not apart from this reality. Biochemical markers pretends to enhance its early diagnosis. Objective: to determine myeloperoxidase activity (MPO), lipid profile and thyroid function, in patients who suffer from Alzheimer´s disease. Methods: it was a case and control analytic observational study, in patients from the Santa Clara polyclinic. The MPO activity, total cholesterol, LDL-c, HDL-c, total triglycerides, VLDL, total T₃ and T₄, and TSH were determined in serum of both groups. Results: no association was found between MPO activity and the presence of the disease (p = 0.348).There was an almost absolute predominance of low levels of HDL-c, more evident in cases (0.43mmol/L), the levels of T₃ tended to be close to the lower limit of the physiological range (1.46nmol/L), a relevant finding was a general presence of subclinical hypothyroidism (23.75 %), with no significant differences between groups. Conclusions: The Alzheimer´s disease keeps showing its increasing with age and it is more common in females. High levels of LDL-c and low of HDL-c are frequent in the elderly. Higher levels of HDL-c and T₃, this last one into the physiological range, act as protectors against the disease. The subclinical hypothyroidism is present and remains hidden in many of the elder with Alzheimer or not. In a high number of patients, coexist Alzheimer´s disease and some diseases from the metabolic syndrome, as dyslipidemias.

Introducción: La diabetes mellitus tipo 2 se caracteriza por la hiperglucemia debido a la insuficiente producción de insulina de las células β. La mieloperoxidasa promueve el estrés oxidativo durante la inflamación y la ceruloplasmina se considera su inhibidor endógeno.

Objetivo: Evaluar la relación entre la ceruloplasmina y la mieloperoxidasa, determinadas simultáneamente en el suero de pacientes diabéticos tipo 2.

Métodos: Se estudiaron 362 pacientes diabéticos tipo 2 y 110 sujetos sanos. La actividad sérica de la ceruloplasmina se determinó por el método de Siotto; y el de la mieloperoxidasa, por el de Kraeisz.

Resultados: El 72 % de los pacientes diabéticos tenían hiperglucemia y el 77 % presentaba obesidad abdominal. Las actividades de ambas enzimas se incrementaron significativamente en relación con el grupo control. El coeficiente de correlación de la actividad enzimática resultó bajo. El cociente R_MPO/CP de los pacientes diabéticos superó el de los controles. La ceruloplasmina no inhibió la mieloperoxidasa.

Conclusiones: Predominó la mieloperoxidasa, por tanto, no se manifestó el efecto inhibitorio de la ceruloplasmina. La elevada actividad de la mieloperoxidasa se asocia con un agravamiento del cuadro clínico del paciente diabético.